Mediford Corporation

Contact us

Contact us
© Mediford Corporation

Nonclinical Contract Research

We contribute to the health of society through our reliable quality and advanced testing technologies.

Nonclinical Contract Research

Since our service started in 1977, we have served as a partner in R&D for private companies in the pharmaceutical, food, and other industries, as well as government agencies and academic institutions in a variety of fields, including pharmaceuticals, regenerative medicine, medical devices, agricultural chemicals, chemical substances, and cosmetics. We provide a high level of service through our advanced technologies, deep knowledge, and the comprehensive capabilities we have developed through many years of experience.

We offer a wide range of services from safety, pharmacodynamic, and pharmacokinetic testing for regulatory applications, to exploratory studies in the early stages of research and development as well as consulting services. Our facilities are compliant with GLP (Good Laboratory Practice) for pharmaceuticals, medical devices, regenerative medicine products, agricultural chemicals, Chemical Substances Control Law, and more.

Strengths of mediford's Nonclinical Contract Research

We provide total support from basic research and planning to a diverse array of studies covering toxicity, pharmacology, and pharmacokinetics, as well as the transition to the clinical phase and regulatory compliance. We also provide flexible support for project management, exploratory screening, and new treatment modality evaluation.

In addition to JSTP and JCVP certified pathologists, we have experienced professionals such as veterinarians, pharmacists, laboratory animal technicians, and JSOT certified toxicologists on our team. We provide tailor-made services for the evaluation of new treatment modalities and new products, including the start-up of new evaluation systems.

We have obtained full accreditation from AAALAC International, an international nonprofit organization that evaluates test facilities for humane management of animals. In compliance with relevant laws and regulations on laboratory animal welfare, we provide the necessary education and training for personnel handling test animals to enhance environmental enrichment for animal welfare.

Advanced Solutions

Best Practice hERG Assay
Best Practice hERG Assay

hERG channel plays an important role in cardiac safety assessment. Mediford performs Best Practice hERG assay in compliance with GLP (Good Laboratory Practice) according to the new ICH S7B Guideline Q&As. Our staff’s proficiency with the patch-clamp method provides our clients with high-quality data quickly and efficiently.

Microsampling
Microsampling

Mediford Corporation has introduced microsampling for non-clinical toxicity studies taking into consideration the 3Rs of animal testing. Microsampling is a technique in which a small amount of blood is collected to measure drug concentrations. By using this technique, fewer animals are used than with conventional methods, and the amount of test substance required can be reduced, which is expected to result in total costs being lower.

Patient-Derived Xenografts (PDX) for Drug Development
Patient-Derived Xenografts (PDX) for Drug Development

Mediford Corporation offers a variety of contract services from establishment and banking of PDX-derived cell lines to conducting pharmacological studies at the GLP-certified facilities of Kumamoto Laboratories. The PDX models are more predictive of clinical outcomes than conventional "cancer cell lines" and will be useful for your research and development purposes.

Patient-Derived Cells (PDC) for Drug Development

Mediford Corporation provides various contract services using clinical isolates (PDC: Patient-Derived Cell) established at the National Cancer Center in Japan.

Contract Services for Regenerative Medicine Products
Regenerative Medicine Products Development Support

We provide a wide range of services in the development of regenerative medicine products from consulting to medical writing for diseases that are difficult to treat with conventional methods. We support each stage of the development process up to submission of application for approval by providing contract services that meet a wide variety of research needs, including toxicity studies (GLP), efficacy and biodistribution studies (reliability standards), and medical writing at research facilities fully accredited by AAALAC.